TY - JOUR
T1 - Characterization of the V4 and T1 polymorphisms of ADAM33 gene and its association with the development of asthma
AU - Vega-Clarisa, Arrascue
AU - Núñez-Rossana, Menéndez
AU - Celestino-Segura, Walter Gutiérrez
AU - Serquén-López, Luis Miguel
AU - Monsalve-Mera, Alain
N1 - Publisher Copyright:
© Article published by the Magazine of the Faculty of Human Medicine of the Ricardo Palma University. It is an open access article, distributed under the terms of the Creative Commons License: Creative Commons Attribution 4.0 International, CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/), that allows non-commercial use, distribution and reproduction in any medium, provided that the original work is duly cited. For commercial use, please contact [email protected]
PY - 2021/4/1
Y1 - 2021/4/1
N2 - Objectives: To determine the association between the presence of V4 polymorphisms of the ADAM33 gene and asthma disease and to describe the frequency of T1 polymorphism in patients from a hospital in the Lambayeque region. Method: Design of cases and controls. Location: Hospital Almanzor Aguinaga Asenjo - EsSalud, level of complexity III-1. Population: patients between 5-17 years old attended by an outpatient clinic. The cases were patients diagnosed according to the Global Initiative for Asthma (GINA) 2016 guidelines. Controls were patients without a diagnosis of any chronic lung disease or a family history of asthma. Results: In most cases, both cases and controls did not present the V4 polymorphism, I feel positive only in 46% of cases and 31% of controls. When the association between the V4 polymorphism and the presence of asthma was evaluated, the OR was 1.93 (95% CI: 0.62 - 6.00), with a non-significant value (p = 0.196) for the Xi test -Pearson square. However, the T1 polymorphism was present in 87% of cases; and the proportion of Tumbesinos with the mutation was much lower than that of other regions. Conclusions: No association was found between the V4 polymorphism and the presence of asthma in patients from a Lambayeque hospital. The T1 polymorphism occurs quite frequently in asthmatic patients at Hospital Almanzor Aguinaga Asenjo - ESSalud.
AB - Objectives: To determine the association between the presence of V4 polymorphisms of the ADAM33 gene and asthma disease and to describe the frequency of T1 polymorphism in patients from a hospital in the Lambayeque region. Method: Design of cases and controls. Location: Hospital Almanzor Aguinaga Asenjo - EsSalud, level of complexity III-1. Population: patients between 5-17 years old attended by an outpatient clinic. The cases were patients diagnosed according to the Global Initiative for Asthma (GINA) 2016 guidelines. Controls were patients without a diagnosis of any chronic lung disease or a family history of asthma. Results: In most cases, both cases and controls did not present the V4 polymorphism, I feel positive only in 46% of cases and 31% of controls. When the association between the V4 polymorphism and the presence of asthma was evaluated, the OR was 1.93 (95% CI: 0.62 - 6.00), with a non-significant value (p = 0.196) for the Xi test -Pearson square. However, the T1 polymorphism was present in 87% of cases; and the proportion of Tumbesinos with the mutation was much lower than that of other regions. Conclusions: No association was found between the V4 polymorphism and the presence of asthma in patients from a Lambayeque hospital. The T1 polymorphism occurs quite frequently in asthmatic patients at Hospital Almanzor Aguinaga Asenjo - ESSalud.
KW - ADAM proteins (source: MeSH NLM)
KW - Asthma
KW - SNPs
UR - https://www.scopus.com/pages/publications/85176001238
U2 - 10.25176/RFMH.V21I2.3450
DO - 10.25176/RFMH.V21I2.3450
M3 - Article
AN - SCOPUS:85176001238
SN - 1814-5469
VL - 21
SP - 261
EP - 268
JO - Revista de la Facultad de Medicina Humana
JF - Revista de la Facultad de Medicina Humana
IS - 2
ER -